NOTCH1 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comNOTCH1 Polyclonal Antibody for Human(Homo sapiens)

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NOTCH1 (Gene name),

Neurogenic locus notch homolog protein 1 (Protein name ), NOTC1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

NOTCH1(TAN1);

Protein name:

Neurogenic locus notch homolog protein 1(Notch 1;hN1);

Alternative:

Translocation-associated notch protein TAN-1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization.

Function:

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia.

Subcellular Location:

Notch 1 intracellular domain Nucleus Following proteolytical processing NICD is translocated to the nucleus.

Protein Attributes:

Sequence length:

2555

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2555:

PEAFK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P46531

STRING:

9606.ENSP00000277541

UniGene:

Hs.495473

KEGG:

hsa:4851

Pfam:

PF00023

MIM:

109730

String:

P46531

Uniprot:

P46531

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ELISA Kit for Human Notch 1

Cat.:

E0501h

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96T

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ELISA Kit for Human Notch 1

Cat.:

E0501r

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96T

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ELISA Kit for Human Notch 1

Cat.:

E0501m

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96T

CLIA Kit for Human Notch 1

Cat.:

U0501m

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Packing:

96T

CLIA Kit for Human Notch 1

Cat.:

U0501h

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Manual:

Looking for manual.

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96T

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CLIA Kit for Human Notch 1

Cat.:

U0501r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Notch 1

Cat.:

P0501Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Notch 1

Cat.:

P0501Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Notch 1

Cat.:

P0501Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Notch 1

Protein for Human Notch 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Complete human notch 1 (hN1) cDNA sequence."
Mann R.S. , Blaumueller C.M. , Zagouras P.
Submitted (2000-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
2.

"DNA sequence and analysis of human chromosome 9."
Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms."
Ellisen L.W. , Bird J. , West D.C. , Soreng A.L. , Reynolds T.C. , Smith S.D. , Sklar J.
Cell66:649-661(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-2443
4.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 489-2555
tissue: Aortic endothelium.
5.

"Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor."
Coleman M.L. , McDonough M.A. , Hewitson K.S. , Coles C. , Mecinovic J. , Edelmann M. , Cook K.M. , Cockman M.E. , Lancaster D.E. , Kessler B.M. , Oldham N.J. , Ratcliffe P.J. , Schofield C.J.
J. Biol. Chem.282:24027-24038(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1947-1962;INTERACTION WITH HIF1AN;HYDROXYLATION AT ASN-1955;IDENTIFICATION BY MASS SPECTROMETRY
6.

"Human ligands of the Notch receptor."
Gray G.E. , Mann R.S. , Mitsiadis E. , Henrique D. , Carcangiu M.-L. , Banks A. , Leiman J. , Ward D. , Ish-Horowitz D. , Artavanis-Tsakonas S.
Am. J. Pathol.154:785-794(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF LIGANDS
7.

"Human deltex is a conserved regulator of Notch signalling."
Matsuno K. , Eastman D. , Mitsiades T. , Quinn A.M. , Carcanciu M.L. , Ordentlich P. , Kadesch T. , Artavanis-Tsakonas S.
Nat. Genet.19:74-78(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DTX1
8.

"SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function."
Zhou S. , Fujimuro M. , Hsieh J.J. , Chen L. , Miyamoto A. , Weinmaster G. , Hayward S.D.
Mol. Cell. Biol.20:2400-2410(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNW1
9.

"MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors."
Wu L. , Aster J.C. , Blacklow S.C. , Lake R. , Artavanis-Tsakonas S. , Griffin J.D.
Nat. Genet.26:484-489(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAML1
10.

"Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors."
Wu L. , Sun T. , Kobayashi K. , Gao P. , Griffin J.D.
Mol. Cell. Biol.22:7688-7700(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAML2 AND MAML3
11.

"AIP4/Itch regulates Notch receptor degradation in the absence of ligand."
Chastagner P. , Israel A. , Brou C.
PLoS ONE3:E2735-E2735(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY ITCH
12.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
13.

"Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis."
Brutsch R. , Liebler S.S. , Wustehube J. , Bartol A. , Herberich S.E. , Adam M.G. , Telzerow A. , Augustin H.G. , Fischer A.
Circ. Res.107:592-601(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Notch1 binds and induces degradation of Snail in hepatocellular carcinoma."
Lim S.O. , Kim H.S. , Quan X. , Ahn S.M. , Kim H. , Hsieh D. , Seong J.K. , Jung G.
BMC Biol.9:83-83(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNAI1 AND MDM2A
15.

"The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway."
Gupta-Rossi N. , Ortica S. , Meas-Yedid V. , Heuss S. , Moretti J. , Olivo-Marin J.C. , Israel A.
J. Biol. Chem.286:18720-18730(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AAK1
16.

"Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase."
Mo J.S. , Ann E.J. , Yoon J.H. , Jung J. , Choi Y.H. , Kim H.Y. , Ahn J.S. , Kim S.M. , Kim M.Y. , Hong J.A. , Seo M.S. , Lang F. , Choi E.J. , Park H.S.
J. Cell Sci.124:100-112(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SGK1 AND FBXW7
17.

"Assembly of a Notch transcriptional activation complex requires multimerization."
Vasquez-Del Carpio R. , Kaplan F.M. , Weaver K.L. , VanWye J.D. , Alves-Guerra M.C. , Robbins D.J. , Capobianco A.J.
Mol. Cell. Biol.31:1396-1408(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNW1
18.

"The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality."
Boskovski M.T. , Yuan S. , Pedersen N.B. , Goth C.K. , Makova S. , Clausen H. , Brueckner M. , Khokha M.K.
Nature504:456-459(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-232; THR-1402 AND THR-1725;PROTEOLYTIC PROCESSING
19.

"Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1."
Vardar D. , North C.L. , Sanchez-Irizarry C. , Aster J.C. , Blacklow S.C.
Biochemistry42:7061-7067(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1446-1480 IN COMPLEX WITH CALCIUM IONS;DISULFIDE BONDS
20.

"Structural and functional properties of the human notch-1 ligand binding region."
Hambleton S. , Valeyev N.V. , Muranyi A. , Knott V. , Werner J.M. , McMichael A.J. , Handford P.A. , Downing A.K.
Structure12:2173-2183(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 411-526
21.

"High-resolution crystal structure of the human Notch 1 ankyrin domain."
Ehebauer M.T. , Chirgadze D.Y. , Hayward P. , Martinez Arias A. , Blundell T.L.
Biochem. J.392:13-20(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1872-2114
22.

"Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes."
Nam Y. , Sliz P. , Song L. , Aster J.C. , Blacklow S.C.
Cell124:973-983(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 1872-2126 IN COMPLEX WITH RBPSUH AND MAML1
23.

"Mutations in NOTCH1 cause aortic valve disease."
Garg V. , Muth A.N. , Ransom J.F. , Schluterman M.K. , Barnes R. , King I.N. , Grossfeld P.D. , Srivastava D.
Nature437:270-274(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN AOVD1

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